UW scientists working with mice to pioneer Alzheimer’s remedy


MADISON, Wis. – UW researchers are doing the job with mice to uncover a new opportunity therapy for Alzheimer’s sickness.

Officials reported a examine, published Monday, showed that superior activity of the gene Nrf2 slowed cognitive and bodily decrease in mice.

The gene also decreased the accumulation of sticky proteins in the mice’s brains. The proteins, termed tau and beta-amyloid, are a marker of Alzheimer’s in human beings.

“The extent of the reduction in beta-amyloid and tau and the just about comprehensive reversal of the genetic adjustments is very significant,” UW College of Pharmacy professor Jeffrey Johnson explained. “I was stunned. I under no circumstances believed we’d get that outcome.”

Johnson is foremost the job, with support from scientists at the College of Edinburgh.

Scientists will now work to locate ways of securely escalating Nrf2 exercise in human beings as a procedure for Alzheimer’s.

Nrf2 is also a therapeutic concentrate on for treating Parkinson’s condition and ALS.