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Study From Residence At ICS Study (Worldwide Correspondence School)

Exercising is an environment friendly way protecting your body fit and toned up. With the right amount of workouts, you will stay healthy and have a better lifestyle. Nicole contributed to the ebook “The Body Sculpting Bible for Women : The Approach to Physical Perfection”. Like I pointed out earlier, not all fitness models are fitness or determine opponents, however plenty of them are. Okay, I do know this one is just a little completely different, however India is technically part of Asia and I haven’t got any articles for “Indian Fitness Girls” so here is the first Indian fitness mannequin that I ever remember seeing, Amrit Dhaliwal.

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In accordance with the FTC, Reebok had been unable to substantiate its claims that the sneakers improve decrease physique shape and improve muscle activity significantly. That lead her again into Fitness Competitions where ultimately, at the Nationwide Physique Committee Staff Universe present in New York, she positioned second and got her IFBB Professional Card.

As energy depends upon vitamin, proper vitamin is vital to physical fitness. Right here is my eighth Hub dedicated to feminine determine competitors and fitness competitors. Sure she is ripped and modern, however there may be also a LOT of energy in those muscle mass.

If body or spirit needs refreshing, these are the places to go to, any time of life. Retro type suits are usually extra figure flattering for a variety of body varieties, and are nice modest alternate options to quite a lot of the skimpy fits out there. She was voted the 36th greatest ladies’s wrestler of all-time by Pro Wrestling Illustrated, but you’ll have never heard of Rita Cortez.…

Eli Lilly says other COVID-19 antibody drug trials ongoing after study halted for safety concern

By Carl O’Donnell and Michael Erman



a large building: FILE PHOTO: Eli Lilly logo is shown on one of their offices in San Diego


© Reuters/MIKE BLAKE
FILE PHOTO: Eli Lilly logo is shown on one of their offices in San Diego

(Reuters) – Eli Lilly & Co on Wednesday said other trials of its experimental coronavirus antibody therapy remain on track after a government-run study testing the treatment in hospitalized COVID-19 patients was paused due to safety concerns.

Lilly said on Tuesday that an independent safety monitoring board requested a pause in the trial, called ACTIV-3, due to a potential safety issue.

The National Institutes of Health (NIH), which is collaborating with Lilly on the trial, said the advisory board paused the trial after seeing a “difference in clinical status” between patients on Lilly’s drug on those who received a placebo, without providing further detail.

Lilly on Wednesday said the paused trial is distinct from others it is conducting because it focuses on hospitalized patients who are more severely ill and being treated with other drugs as well, including Gilead Sciences Inc’s antiviral remdesivir.

The company had already asked U.S. regulators for an emergency use authorization (EUA) for the antibody drug, called bamlanivimab or LY-CoV555, to treat mild to moderate COVID-19 patients, based on interim data from a different study in those less severe illness. It is also testing the drug in nursing homes to see if it can prevent staff and residents from getting infected.

The U.S. Food and Drug Administration did not immediately respond to a request for comment on the status of the EUA application.

LY-CoV555 is similar to the experimental dual-antibody therapy from Regeneron Pharmaceuticals Inc that was used to treat U.S. President Donald Trump. That treatment is also awaiting clearance by U.S. regulators.

Trump touted both drugs as being tantamount to cures in a video he posted last week after being released from the hospital.

Lilly said in a statement that these type of treatments may prove to be less beneficial for hospitalized patients than for those with more mild cases of the disease. A Lilly spokeswoman declined to comment further on why the trial was halted.

The paused trial is being conducted in partnership with the U.S. National Institute of Allergy and Infectious Diseases, a division of the NIH that is working with several drugmakers on COVID-19 treatments and vaccines.

It was halted at the request of an independent oversight panel, called a Data Safety and Monitoring Board (DSMB). It is not uncommon to pause drug trials to investigate safety concerns, and such actions do not necessarily indicate a serious problem.

“Lilly trusts the judgment of the independent DSMB and supports its decisions to exercise caution in ensuring the safety of the patients participating in this study,” the company said in a statement.

(Reporting by Carl O’Donnell; Editing by Chizu Nomiyama and Bill Berkrot)

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More Than 15 Percent Of Ohio Kids Considered Obese: Study

CLEVELAND — More than 15 percent of Ohio children are considered obese.

Ohio has one of the highest obesity rates in the nation for children ages 10 to 17, according to a new study by the Robert Wood Johnson Foundation. Roughly one in seven Ohio kids are considered obese.

“Childhood obesity remains an epidemic in this country,” said Jamie Bussel, senior program officer at the Robert Wood Johnson Foundation .

Ohio’s obesity rate for kids 10 to 17 is 15.7 percent. The national obesity rate for that age group is 15.5 percent. Ohio has the 20th highest youth obesity rate in the nation.

Poverty is one of the leading contributing factors to youth obesity, the Foundation found. With the coronavirus pandemic causing shutdowns and mass layoffs around the nation, Ohio and the U.S.’s youth obesity crisis may have grown worse.

“The COVID-19 pandemic and ongoing economic recession have worsened many of the broader factors we know contribute to obesity, including poverty and health disparities. We must confront these current crises in ways that also support long-term health and equity for all children and families in the United States,” Bussel said.

Obesity rates tend to also reveal racial, ethnic and economic disparities. Black, Hispanic and Native American children have higher obesity rates than white or Asian children, the Foundation said.

“We’ve seen these disparities for decades when it comes to childhood obesity rates,” Bussel said. “This year, we’ve also seen people of color and people with low incomes hit hardest by the COVID-19 pandemic. In both cases these outcomes reflect decades of disinvestment in specific communities and specific groups of people, often driven by the systemic racism and discrimination that are still so prevalent in our society.”

To counteract escalating obesity rates, the Foundation recommended the federal government increase SNAP’s maximum benefit level and expand waivers allowing school districts to feed students and the community.

The data on Ohio’s youth obesity rate is included in the Robert Wood Johnson Foundation’s new report, “State of Childhood Obesity: Prioritizing Children’s Health During the Pandemic.”

The report uses data from the 2018-2019 National Survey of Children’s Health and an analysis conducted by the Health Resources and Services Administration’s Maternal and Child Health Bureau.

This article originally appeared on the Across Ohio Patch

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It’s Tough to Change the Minds of ‘Vaccine-Hesitant’ Parents, Study Finds | Health News

By Amy Norton
HealthDay Reporter

(HealthDay)

WEDNESDAY, Oct. 14, 2020 (HealthDay News) — When parents have concerns about the safety of childhood vaccinations, it can be tough to change their minds, as a new study shows.

The study involved “vaccine-hesitant” parents — a group distinct from the staunch “anti-vaxxer” crowd. They have worries about one or more routine vaccines, and question whether the benefits for their child are worthwhile.

Even though those parents are not “adamantly” opposed to vaccinations, it can still be hard for pediatricians to allay their concerns, said Jason Glanz, lead researcher on the study.

So Glanz and his colleagues looked at whether giving parents more information — online material “tailored” to their specific concerns — might help.

It didn’t. Parents who received the information were no more likely to have their babies up to date on vaccinations than other parents were, the study found.

The news was not all bad. Overall, more than 90% of babies in the study were all caught up on vaccinations.

So it may have been difficult to improve upon those numbers, according to Glanz, who is based at Kaiser Permanente Colorado’s Institute for Health Research in Aurora.

But, he said, it’s also possible the customized information reinforced some parents’ worries.

“It might have done more harm than good,” Glanz said.

That’s because among vaccine-hesitant parents, those who were directed to general information that was not tailored, had the highest vaccination rates — at 88%.

The findings were published online Oct. 12 in Pediatrics.

Childhood vaccination rates in the United States are generally high. But studies show that about 10% of parents either delay or refuse vaccinations for their kids — generally over safety worries.

Routine childhood vaccines have a long history of safe use, Glanz said, but some parents have questions. They may have heard that certain ingredients in vaccines are not safe, or worry that their baby is being given “too many” immunizations in a short time.

And during a busy pediatrician visit, Glanz said, it can be hard to address all those questions.

So his team tested a web-based tactic to augment routine checkups. They randomly assigned 824 pregnant women and new parents to one of three groups: One received standard vaccine information from their pediatrician; another was directed to the study website for additional, but general, information on immunizations; and the third received tailored information from the website.

That tailoring was done with the help of a survey that asked parents about their vaccine beliefs and concerns.

In the end, however, the targeted messaging flopped. It made no difference among parents overall: Across the three groups, between 91% and 93% of babies were up to date on vaccinations at 15 months of age.

And among the 98 parents who were deemed vaccine-hesitant, the tactic seemed to backfire: Only 67% of those babies were up to date compared to 88% of those whose parents received general vaccine information. The rate was 75% in the standard-care group.

Dr. Edgar Marcuse,

Study: Health Systems, Govt Responses Linked to Virus Tolls | World News

BERLIN (AP) — Scientists say a comparison of 21 developed countries during the start of the coronavirus pandemic shows that those with early lockdowns and well-prepared national health systems avoided large numbers of additional deaths due to the outbreak.

In a study published Wednesday by the journal Nature Medicine, researchers used the number of weekly deaths in 19 European countries, New Zealand and Australia over the past decade to estimate how many people would have died from mid-February to May 2020 had the pandemic not happened.

The authors, led by Majid Ezzati of Imperial College London, then compared the predicted number of deaths to the actual reported figure during that period to determine how many likely occurred due to the pandemic. Such models of ‘excess mortality’ are commonly used by public health officials to better understand disease outbreaks and the effectiveness of counter-measures.

The study found there were about 206,000 excess deaths across the 21 countries during the period, a figure that conforms to independent estimates. In Spain, the number of deaths was 38% higher than would have been expected without the pandemic, while in England and Wales it was 37% higher.

Italy, Scotland and Belgium also had significant excess deaths, while in some countries there was no marked change or even — as in the case of Bulgaria — a decrease.

While the authors note that there are differences in the compositions of populations, such as age and the prevalence of pre-existing conditions that contribute to mortality rates, government efforts to suppress transmission of the virus and the ability of national health systems to cope with the pandemic also played a role.

Amitava Banerjee, a professor of clinical data science at University College London who wasn’t involved in the study, said it was well designed and had used standardized methods.

He noted that the comparison between death rates in the United Kingdom and New Zealand, where the age of the population and the rates of pre-existing conditions such as obesity are similar, supports the argument that other factors contributed to the differing mortality figures.

“Even if vaccines and better treatments for severe (COVID-19) infection are developed, the way to minimise excess deaths is to reduce the infection rate through population level measures,” said Banerjee.

These include lockdowns, protecting high risk groups,and establishing effective “test, trace and isolate” systems, he said.

Follow AP’s pandemic coverage at http://apnews.com/VirusOutbreak and https://apnews.com/UnderstandingtheOutbreak

Copyright 2020 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Restore EF Study Demonstrates Impella-Supported High-Risk PCI Improves Left Ventricular Ejection Fraction

The Restore EF Study demonstrates the use of contemporary best practices, including attempting a more complete revascularization with Impella-supported high-risk PCI, is associated with significant improvement of left ventricular ejection fraction (LVEF), heart failure symptoms, and anginal symptoms at follow up. The interim analysis was presented today by Mitul Patel, MD, an interventional cardiologist at UC San Diego Health, at TCT Connect, the 32nd annual scientific symposium of the Cardiovascular Research Foundation.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20201014005286/en/

Figure 1 (Graphic: Business Wire)

The ongoing, multi-center, prospective, single-arm study enrolled 193 consecutive qualified patients who underwent a Protected PCI procedure with Impella between September 2019 and September 2020 at 19 hospitals in the United States, representing a variety of hospital settings including rural, urban, community and academic centers. The interim analysis showed:

  • Significant median LVEF improvement from baseline to 90-day follow up (31% to 45% p<0.0001). LVEF improvement at 90 days is the study’s primary endpoint. (see figure 1)

  • Significant reduction of heart failure symptoms with 80% reduction in New York Heart Association (NYHA) classification III/IV at follow up (54% to 11% p<0.001). (see figure 2)

  • Significant reduction of anginal symptoms with 99% reduction in Canadian Cardiovascular Society (CCS) classification III/IV at follow up (70% to 1% p<0.0001). (see figure 3)

“Restore EF demonstrates Impella-supported PCI patients have shown a significant LVEF improvement at 90 days. The study also found a significant improvement in heart failure and anginal symptoms assessed with NYHA and CCS functional classifications,” said Dr. Patel. “Taken together, this data validates best practices for treating high-risk PCI patients, including the use of Impella to achieve a complete revascularization in a single setting.”

“High-risk PCI patients often pose a revascularization challenge due to patient comorbidities, poor LV function, and adverse hemodynamics, which drive worse outcomes. This research demonstrates the rationale for using Impella support during high-risk PCI to maintain coronary perfusion and support hemodynamics during periods of myocardial ischemia during long or repeated balloon inflations or atherectomy runs. This allows providers to achieve complete functional revascularization and the best possible outcomes for our patients,” said Jason Wollmuth, MD, an interventional cardiologist at Providence Health and Vascular Institute and a co-principal investigator of the Restore EF Study.

Restore EF is part of a growing body of evidence demonstrating Protected PCI with Impella is associated with improvements in LVEF and heart failure symptoms. That research includes:

  • Burzotta et al., which found Protected PCI with Impella is associated with LVEF improvement in complex high-risk patients at 90 days (27% vs. 33%, p<0.001). The authors also found more complete revascularization is associated with increased LVEF and survival.

  • PROTECT II Randomized Controlled Trial, which found Protected PCI with Impella led to a 58% improvement in NYHA class III and IV heart failure symptoms at 90 days (p<0.001). The trial also found, during follow up after Protected PCI with Impella, patients had a 22% improvement in LVEF (p<0.001).

  • Maini et al.,

Pfizer to enroll kids as young as 12 in COVID-19 vaccine study

(Reuters) – Pfizer Inc will enroll participants as young as 12 in its large, late-stage COVID-19 vaccine trial to understand how it works in a wider age group.

While severe COVID-19 symptoms are extremely rare in infected children, they can pass on the virus to high-risk groups such as the elderly.

That makes determining the effectiveness of a potential vaccine in children crucial, as vaccines work differently in kids and adults, the FDA said in its guidelines https://www.fda.gov/media/139638/download in June.

The U.S. Food and Drug Administration (FDA) granted permission to the drugmaker and German partner BioNTech SE to enroll younger participants this month, according to an update on the U.S. company’s website https://www.pfizer.com/science/coronavirus/vaccine on Monday.

Last month, Pfizer scaled up its trial to about 44,000 participants, from up to 30,000, to enroll people as young as 16 and those with chronic, stable HIV, hepatitis C and hepatitis B.

The company said on Tuesday it would enroll children in its study based on satisfactory safety data in older adolescents and young adults, but did not specify a timeline.

Pfizer is racing to develop a safe and effective vaccine for the new coronavirus with rivals such as Moderna Inc, AstraZeneca Plc and Johnson & Johnson.

Late-stage vaccine trials initiated by Moderna, J&J and Novavax Inc are testing their respective candidates only in adults.

AstraZeneca’s U.K. vaccine trial, targeting more than 12,000 volunteers, will have one out of 11 subgroups with children 5 to 12 years of age. Chief Executive Officer Pascal Soriot said last month that tests on children had not yet started.

(Reporting by Manojna Maddipatla in Bengaluru and Ludwig Burger in Frankfurt; Editing by Sriraj Kalluvila and Shinjini Ganguli)

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Study: Less restrictive reproductive rights reduce birth complications risk by 7%

Oct. 13 (UPI) — Women living in states with less restrictive reproductive rights policies are 7% less likely have low birth weight babies than those living in states with more stringent laws, according to an analysis published Tuesday by the American Journal of Preventive Medicine.

The risk was 8% lower for Black women living in less-restrictive states, the data showed.

“Our study provides evidence that reproductive rights policies play a critical role in advancing maternal and child health equity,” study co-author May Sudhinaraset, of the UCLA Fielding School of Public Health, said in a statement.

Since the Supreme Court’s decision in Roe v. Wade in 1973, which effectively legalized abortion, states have had “substantial discretion” in creating policies governing whether Medicaid covers the costs of contraception or reproductive health care.

Some states have taken steps that effectively limit access to abortion services and other reproductive care, Sudhinaraset and her colleagues said.

Black women are more likely to die in pregnancy and childbirth than any other race group, experience more maternal health complications than White women and generally have lower quality maternity care, they said.

In addition, women of color are more likely to experience adverse birth outcomes.

Compared to infants of normal weight, low-birth-weight babies face many potential health complications, including infections early in life and long-term problems, such as delayed motor and social development or learning disabilities.

Sudhinaraset and her colleagues analyzed birth record data for the nearly 4 million births that occurred in the 50 states and Washington, D.C., in 2016, comparing reproductive rights policies and adverse birth outcomes in each state.

They also evaluated if the associations were different for women of color and immigrants.

The findings indicate that expanding reproductive rights may reduce the risk of low-birth weight, particularly for U.S.-born Black women, the researchers said.

“Important policy levers can and should be implemented to improve women’s reproductive health overall, including increasing abortion access and mandatory sex education in schools,” Sudhinaraset said.

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Study: Many older Americans with heart failure take 10 or more meds

When older people hospitalized for heart failure are sent home, they are often given a whopping 10 medications to take for a variety of conditions.

But is this “polypharmacy” practice necessary, or does it just place a bigger burden on already frail patients?

It’s not a question so much of the quantity of the medications, but whether the medications patients are taking are the right ones for them, said senior study author Dr. Parag Goyal, a geriatric cardiologist at NewYork-Presbyterian in New York City.

“It’s not just that we’re not starting the right medications, there may be situations where we’re not stopping the wrong medications as well,” Goyal said. “I think we need to look at the medication that older adults with heart failure take in a more holistic fashion.”

For the study, Goyal’s team examined the medical charts of 558 adults aged 65 and older who were hospitalized in the United States between 2003 and 2014.

When admitted, 84% of the patients were taking five or more medications and 42% were taking 10 or more. When discharged, those numbers had risen to 95% of patients prescribed five or more medications and 55% taking 10 or more.

Most of the prescribed medicines were not for the patients’ heart failure or heart conditions, the researchers said.

A larger medication burden increases the risk of adverse drug reactions, which could lead to patients ending up in the hospital, Goyal explained. It can also require more work for the patient, which can have an impact on quality of life.

“It’s a big challenge,” Goyal said. “How exactly do you reconcile the fact that a lot of these medications are meant to prevent events and to help patients feel better with the concept that as the number of medications rise, you might be negatively affecting these parameters?”

The study found that about 90% of older adults with heart failure have at least three other medical conditions. More than 60% have at least five other conditions.

The findings were published online Oct. 13 in the journal Circulation: Heart Failure.

The researchers concluded that there is a need to develop strategies that can alleviate the negative effects of polypharmacy. Among the drugs that may be overused are proton-pump inhibitors, which reduce stomach acid.

There are a host of medications patients may have been taking for years that could be reviewed, Goyal noted.

However, the study suggested that the benefits of medication may outweigh the risks of polypharmacy for people with certain conditions, including chronic obstructive pulmonary disease COPD and diabetes.

Some medications already are multipurpose, including one that treats diabetes and heart failure, said Dr. Gregg Fonarow, chief of the University of California, Los Angeles, division of cardiology.

“That doesn’t mean there are not some medications that are not necessary and could be either reduced or consolidated, but that for patients with heart failure that have a number of other comorbid conditions there are a number of medications that are proven in randomized trials, proven in

Hurricane Irma caused over 400 senior deaths in Florida, study says

The aftereffects of 2017’s Hurricane Irma appear to have killed more than 400 senior residents of Florida nursing homes, a new university study shows.

Researchers at the University of South Florida and Brown University concluded that 433 additional patients died within 90 days of the September 2017 storm, compared to the same period in 2015, when there were no hurricanes.

Their study examined health data for 62,000 patients at 640 Florida nursing homes obtained from the Centers for Medicare and Medicaid Services, according to the Tampa Bay Times. The study was recently released.

HURRICANE DELTA’S DEATH TOLL AT 4 AS LOUISIANA OFFICIALS STRESS GENERATOR SAFETY AFTER DEADLY FIRE

The study was prompted by the heat-related deaths of 12 residents at a Broward County nursing home. Authorities said those deaths were caused when the storm disabled the central air conditioning and the staff failed to move patients to a nearby hospital.

The study was prompted by the heat-related deaths of 12 residents at a Broward County nursing home.

The study was prompted by the heat-related deaths of 12 residents at a Broward County nursing home.
(John McCall/South Florida Sun-Sentinel via AP, File)

An administrator and three nurses who worked at the Rehabilitation Center at Hollywood Hills have been charged with failing to prevent the deaths.

The researchers found that long-term nursing home residents suffered not only increased mortality rates after Irma, but more hospitalizations.

‘BUBBLE CURTAIN’ IS THE NEWEST CRAZY HURRICANE-KILLING IDEA

“Nursing homes need to really pay attention to these people when they’re in the process of reacting to a hurricane,” said co-author Lindsay Peterson, a research assistant professor of aging studies at USF.

In this geocolor image captured by GOES-16  and released by the National Oceanic and Atmospheric Administration (NOAA), Hurricane Irma, a potentially catastrophic category 5 hurricane, moves westward, Tuesday morning, Sept. 5, 2017, in the Atlantic Ocean toward the Leeward Islands.

In this geocolor image captured by GOES-16  and released by the National Oceanic and Atmospheric Administration (NOAA), Hurricane Irma, a potentially catastrophic category 5 hurricane, moves westward, Tuesday morning, Sept. 5, 2017, in the Atlantic Ocean toward the Leeward Islands.
(NOAA via AP)

Brian Lee, director of Families for Better Care, a nonprofit that advocates for better services at long-term care facilities, said the study shows that nursing homes need to do a better job preparing for hurricanes.

“This is an extremely vulnerable population, and nursing homes and other facilities need to do a better job of hardening their facilities to protect our loved ones,” Lee said.

After Irma, Florida required nursing homes and assisted-living facilities to install generators to keep residents cool in case of a storm. But the laws need to be tougher, Lee said.

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Nursing homes need generators that can allow cooling of residents in their rooms, not spot coolers that were used at Hollywood Hills. That required moving residents into large spaces to keep them cool. Fewer than 100 of the state’s long-term care facilities had temporary generators during Irma, the Times reported.

“We need to make sure that facilities can withstand these storms and not worry about transferring residents around and exposing them to potential transfer trauma,” Lee said.

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