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The best DNA testing service is just $99 this Amazon Prime Day

Your genes can tell a lot about you. By going beyond your family tree, you can uncover ancestry markers in your DNA that give you insight into your ancestry and your health. 23andMe is ranked as the best DNA testing kit by many reviewers, and it’s now discounted to just $99.00 for health and ancestry, making it a great buy whether you want it for yourself or as an early holiday gift for a loved one. 

It works with a simple saliva test you perform at home and send to 23andMe. This test collects your DNA, and the extracted genetic data reveals your ancestral composition and even the percentage of DNA that you share with Neanderthals, which interbred with early humans.

This offer also includes health insights, providing you with information about how your genetics can influence your chances of developing certain health conditions or if you are a carrier for some inherited conditions.

This DNA kit can identify health-related genetic markers for diseases such as celiac disease, late-onset Alzheimer’s disease and Parkinson’s disease. 

It can also look for genetic markers for diseases like Type 2 diabetes, using your genetics, ethnicity and age to calculate a percentage likelihood of developing the disease. The test also looks at a gene associated with muscle composition to reveal whether your composition is common or not in elite athletes. The test will also indicate whether the subject is a carrier of genetic traits such as cystic fibrosis, sickle cell anemia and hereditary hearing loss.

There’s even a “cilantro taste aversion” test that will let you know whether you are genetically predisposed to dislike cilantro. Perhaps, you already knew though?

23andMe received approval from the U.S. Food and Drug Administration (FDA) in April 2017 for their kits to report whether customers have hereditary traits that put them at risk for developing genetic diseases, according to the Los Angeles Times. However, the presence of a genetic marker for a health disorder does not necessarily mean that the person will develop that disease, the LA Times reported.

Originally published on Live Science.

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Scientists develop new ‘precision medicine’ approach to treating damaged DNA in pancreatic cancer

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Scientists have developed a new “precision medicine” approach to treating the damaged DNA in the cancer cells of Pancreatic Cancer patients.

The findings mark an important step forward for potential treatment options for pancreatic cancer, improving the options and outcomes for a disease where survival rates have remained stubbornly low.

The study detailing the approach—led by the University of Glasgow and published in Gastroenterology—used cell lines and organoids that were generated from patients with pancreatic cancer to develop new molecular markers that can predict who will respond to drugs targeting DNA damage.

The researchers tested these markers using multiple drugs, and have developed a strategy that are now being taken forward into clinical trial. The trial will help doctors and researchers predict which patient will respond to which one of these drugs, either alone or in combination.

Funding for the trail has come from AstraZeneca and will now be included in the PRIMUS-004 clinical trial as part of the Precision-Panc therapeutic development platform for pancreatic cancer.

PRIMUS-004 is a ground-breaking pancreatic cancer trial, which aims to match patients with more targeted and effective treatment for their tumors. Run by Precision-Panc, a flagship therapeutic development program dedicated to pancreatic cancer—led by the University of Glasgow with major funding from Cancer Research UK—the trial brings a precision medicine approach to pancreatic cancer treatment for the first time in the UK.

The trial will open for recruitment in Glasgow shortly, with 20 other centers throughout the UK to follow.

Although survival for many types of cancer has improved, pancreatic cancer survival has lagged significantly behind in the last 40 years. The disease is particularly hard to treat, partly because it’s often diagnosed at a late stage.

A major limitation to treating pancreatic cancer effectively is that there are very few treatment options for patients with the disease. Currently, some patients with pancreatic cancer cannot repair damaged DNA in the cancer cells, which makes the cancer vulnerable to some new and established drug treatments.

Dr. David Chang, from the University of Glasgow’s Institute of Cancer Sciences, said: “Our study is a huge breakthrough in terms of what might be possible with future treatments. As part of our research, the strategy we’ve developed is extremely promising, and we’re very pleased and proud to see it now be taken into clinical trial. For us, this is a demonstration of a bench-to-bedside precision oncology approach to tackle this terrible disease.”

Michelle Mitchell, Cancer Research UK’s chief executive, said: “We urgently need new ways to treat pancreatic cancer. The disease only has a few treatment options and is generally diagnosed at a late stage, so survival has remained stubbornly low. The Precision Panc study offers a dynamic way to explore new tailored treatments, and it’s fantastic that we now have new drug candidates to add to the PRIMUS-004 trial. We look forward to seeing if these drugs, which have shown promise in the lab, have the same impact for people with pancreatic cancer.”

DNA Dental Comprises the Best Dentist in Dallas, TX, Offering Cosmetic, General, and Restorative Dental Care and Treatment Solutions – Press Release

DNA Dental Comprises the Best Dentist in Dallas, TX, Offering Cosmetic, General, and Restorative Dental Care and Treatment Solutions

Dallas, TX – Dallas, TX residents who are in search of 5-star and premium dental care and treatment solutions can now rest assured that the team at DNA Dental brings this quality of services to them at affordable rates. The dental clinic in Dallas, TX boasts a team of experienced and professional dental specialists who are constantly improving on their dental practice to ensure that each patient is given the attention and care they deserve.

Focused on improving the oral health and wellness of the members of the community, DNA Dental has proudly expanded on its dentistry practice to offer a wide range of dental solutions, including the very best children’s dentistry solutions in the area. Children who come into the dental clinic will have access to the very best and experienced pediatric dentists who are committed to creating the best dental care and treatment experiences using the latest dental tools, technology, and procedures while also aiming for a pain-free dental care and treatment experience.

The entire team of Dentist at DNA Dental also focus on helping children to form the right dental foundations for their oral health and wellness needs. Added to this, the dental clinic boasts of the best Cosmetic Dentist in the Dallas, TX area. The professional cosmetic dentist offers a range of popular cosmetic dental services that are designed to help patients to reach the goal they have for a bright and beautiful smile.

Describing the dental solutions offered at the clinic, Dr. Darya Timin, the spokesperson for DNA Dental said, “Here at DNA Dental, we are committed to providing gentle care to every member of your family. We understand that you may feel nervous about your dental visits, and we are here to help you feel relaxed and comfortable. Our dentists and team are proud to provide quality, gentle dentistry solutions. We invite you to contact our friendly team today to learn more about our comprehensive services and to schedule your next appointment with one of our experienced dentists. Take your next step toward a healthy smile today!”

Serving patients in Dallas, TX, and the surrounding areas, DNA Dental also offers comprehensive restorative dentistry solutions including dental bridges, dental crowns, dental implants, dentures, and dental fillings.

Patients who visit the clinic will have access to the latest dental technologies, as well as a cutting-edge approach to dental care and treatment.

DNA Dental is located at 6162 E Mockingbird Ln Ste 205, Dallas, TX 75214, US. For top-quality dental care and treatment solutions, contact their team by calling +1 214-817-3113 to schedule an appointment. For additional information regarding their services, send an email to [email protected] or visit the dental clinic’s website.

Media Contact
Company Name: DNA Dental
Contact Person: Dr. Darya Timin
Email: Send Email
Phone: +1 214-817-3113
Address:6162 E Mockingbird Ln Ste 205
City: Dallas
State: TX
Country: United States
Website: https://dnadentaldallas.com/

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DNA From Neanderthals Can Make Covid More Severe

Covid-19 patients with a snippet of Neanderthal DNA that crossed into the human genome some 60,000 years ago run a higher risk of severe complications from the disease, researchers have reported.

People infected with the new coronavirus, for example, who carry the genetic coding bequeathed by our early human cousins are three times more likely to need mechanical ventilation, according to a study published Wednesday in Nature.

There are many reasons why some people with Covid-19 wind up in intensive care and other have only light symptoms, or none at all.

Advanced age, being a man, and pre-existing medical problems can all increase the odds of a serious outcome.

But genetic factors can also play a role, as the new findings makes clear.

“It is striking that the genetic heritage from Neanderthals has such tragic consequences during the current pandemic,” said co-author Svante Paabo, director of the department of genetics at the Max Planck Institute for Evolutionary Anthropology.

Recent research by the Covid-19 Host Genetics Initiative revealed that a genetic variant in a particular region of chromosome 3 — one of 23 chromosomes in the human genome — is associated with more severe forms of the disease.

That same region was known to harbour genetic code of Neanderthal origins, so Paabo and co-author Hugo Zeberg, also from Max Planck, decided to look for a link with Covid-19.

People infected with Covid-19 who carry a specific snippet of genetic coding bequeathed by Neanderthals are three times more likely to need mechanical ventilation People infected with Covid-19 who carry a specific snippet of genetic coding bequeathed by Neanderthals are three times more likely to need mechanical ventilation Photo: AFP / STEPHANE DE SAKUTIN

They found that a Neanderthal individual from southern Europe carried an almost identical genetic segment, which spans some 50,000 so-called base pairs, the primary building blocks of DNA.

Tellingly, two Neanderthals found in southern Siberia, along with a specimen from another early human species that also wandered Eurasia, the Denisovans, did not carry the telltale snippet.

Modern humans and Neanderthals could have inherited the gene fragment from a common ancestor some half-million years ago, but it is far more likely to have entered the homo sapiens gene pool through more recent interbreeding, the researchers concluded.

The potentially dangerous string of Neanderthal DNA is not evenly distributed today across the globe, the study showed.

Some 16 percent of Europeans carry it, and about half the population across South Asia, with the highest proportion — 63 percent — found in Bangladesh.

This could help explain why individuals of Bangladeshi descent living in Britain are twice as likely to die from Covid-19 as the general population, the authors speculate.

In East Asia and Africa the gene variant is virtually absent.

About two percent of DNA in non-Africans across the globe originate with Neanderthals, earlier studies have shown.

Denisovan remnants are also widespread but more sporadic, comprising less than one percent of the DNA among Asians and Native Americans, and about five percent of aboriginal Australians and the people of Papua New Guinea.

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