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CDC Study Details ‘Urgent Need’ to Address Coronavirus Spread Among Young Adults | National News

Coronavirus cases among young adults are on the rise, and the Centers for Disease Control and Prevention said there is an “urgent need” to address the trend.

In a study released on Friday, the CDC examined 767 hotspot counties identified during June and July and found that increases in the percent of positive tests among people 24 and younger were followed by several weeks of increasing positivity rates in those aged 25 and older. The trend was particularly true in the South and West.

Photos: Daily Life, Disrupted

TOPSHOT - A passenger in an outfit (R) poses for a picture as a security guard wearing a facemask as a preventive measure against the Covid-19 coronavirus stands nearby on a last century-style boat, featuring a theatrical drama set between the 1920s and 1930s in Wuhan, in Chinas central Hubei province on September 27, 2020. (Photo by Hector RETAMAL / AFP) (Photo by HECTOR RETAMAL/AFP via Getty Images)

Making the findings even more concerning is the fact that a jump in the positivity rate of older age groups is “likely to result in more hospitalizations, severe illnesses, and deaths,” according to CDC.

“There is an urgent need to address transmission among young adult populations, especially given recent increases in COVID-19 incidence among young adults,” the study said.

CDC published a separate, small study on Friday that identified common drivers of behavior that might influence risk for COVID-19 exposure among young adults in Wisconsin. The list included: social or peer pressure, perceived severity of disease outcome and exposure to misinformation, conflicting messages or opposing views regarding masks.

During interviews, young adults said they felt social or peer pressure to not wear a mask and reported receiving “negative reactions” or “odd looks” from people while wearing a mask.

The study said the finding “further underscores the importance of providing clear and consistent messages regarding need for and effectiveness of masks.”

Last week, CDC reported that coronavirus infections among young adults jumped from August to September, with the agency concluding that some of the increase was likely due to colleges and universities resuming in-person classes.

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First lady’s office details safety protocols for White House residence staff

The White House on Tuesday detailed measures taken to protect residence staff from the spread of the coronavirus, including the addition of health consultants, as workers face increased risk from a COVID-19 outbreak in the building.

The first lady’s office said residence staff in direct contact with the first family are tested for COVID-19 daily, and support staff are tested every other day. The White House residence has hired independent health consultants to facilitate additional testing as needed and check on staff and their families.

The residence also added a “well-being” consultant as a resource for workers looking for mental health assistance. Staffers can speak to the consultant anonymously, the first lady’s office said.

“With the recent positive results of the President and First Lady, staff wear full PPE [personal protective equipment] and continue to take all necessary precautions, which include updated procedures to protect against cross contamination,” the East Wing said in a news release.

The East Wing said Tuesday that the residence has been subject to “hospital-grade disinfection policies” since March and encouraged teleworking to the extent that it is possible.

Residence staff have been required to wear masks since April, despite the president flouting that practice himself.

The accounting of health protocols in place in the residence comes days after President TrumpDonald John TrumpState Department revokes visa of Giuliani-linked Ukrainian ally: report White House Gift Shop selling ‘Trump Defeats COVID’ commemorative coin Biden says he should not have called Trump a clown in first debate MORE and first lady Melania TrumpMelania TrumpWhite House Gift Shop selling ‘Trump Defeats COVID’ commemorative coin Hillicon Valley: CEOs of Google, Facebook and Twitter to testify before Senate | European Union police agency warns of increase in cybercrime | Twitter to remove posts hoping for Trump’s death White House not contact tracing Rose Garden event considered possible ‘superspreader’: report MORE tested positive for the highly contagious coronavirus. Since then, the number of positive tests among those in their orbit has ballooned to include at least three press shop staffers, a military aide and two workers in the residence.

The president spent three days in the hospital getting treated for his COVID-19 infection and required supplemental oxygen on Friday and Saturday. He returned to the White House on Monday evening.

But President Trump appears unchanged by his first-hand experience with the virus, telling Americans not to be afraid of the disease and ripping off his mask upon returning to the executive mansion despite still being contagious.

The first lady, by contrast, has put out multiple PSAs urging Americans to wear masks and socially distance. She has been recovering from the virus at the residence, and has said she is doing well.

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Precision medicine uses multiomic details to battle kidney disease

September 10, 2020

6 min read


Source/Disclosures



Disclosures:
Bansal, Eadon, Jones-Smith, Kiryluk, and Sharma report no relevant financial disclosures.

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The value of precision medicine has been shown with the identification of the genetic causes of tumors that differ among patients. Applied to nephrology, precision medicine can offer an earlier look at the potential risk for kidney disease.

“Precision medicine is a personalized approach to disease management of the patient … The goal is to have the right dose, delivered at the right time, for the right patient,” according to Shweta Bansal, MD, an associate professor of nephrology at the University of Texas-San Antonio School of Medicine. “It is not about one approach that fits all patients. It must be tailored.”

The treatment regimen is the last step in precision medicine, Bansal said. The work begins with the detection of the origins of disease through genomics.

“[NIH director] Francis Collins said it most straightforward. Precision medicine is the application of prevention and treatment strategies that take individual variability into account,” Michael Eadon, MD, assistant professor of medicine in the divisions of nephrology and clinical pharmacology at Indiana University School of Medicine, told Nephrology News & Issues. “There has always been an overarching connotation that genomic information, either from your genome or downstream applications like gene expression, would be integrated into evidence-based medicine.”

Kumar Sharma, MD, chief of nephrology and professor of medicine at the University of Texas-San Antonio, said research at the Center for Renal Precision Medicine will reveal the likelihood of chronic kidney disease early in high-risk individuals.

Source: Center for Renal Precision Medicine.

Genomic testing

Two examples of the application of genomics to detect the risk of end-stage kidney disease is research on the efficacy of the drug tolvaptan for patients with autosomal-dominant polycystic kidney disease (ADPKD) and the identification of risk variants in the apolipoprotein L1 (APOL1) gene that can lead to kidney disease.

In a study in Clinical Journal of the American Society of Nephrology, David J. Friedman, MD, and colleagues wrote that many types of severe kidney disease are higher in Black patients than in other patient groups. That disparity is attributed to genetic variants in the apoL1 (APOL1) gene found only in individuals with recent African ancestry, the authors wrote. “These variants greatly increase rates of hypertension-associated ESKD, [focal segmental glomerulosclerosis] FSGS, HIV-associated nephropathy, and other forms of nondiabetic kidney disease.”

Friedman and colleagues said the discovery of the APOL1 risk variants has led to discussions about incorporating genetic testing in the screening process for living kidney donors. Those with the APOL1 genomic makeup could pass

Trump greets supporters following new details of his illness

BETHESDA, Md. (AP) — Infected and contagious, President Donald Trump briefly ventured out in a motorcade on Sunday to salute cheering supporters, a move that disregarded precautions meant to contain the deadly virus that has forced his hospitalization and killed more than 209,000 Americans.

Hours earlier, Trump’s medical team reported that his blood oxygen level dropped suddenly twice in recent days and that they gave him a steroid typically only recommended for the very sick. Still, the doctors said Trump’s health is improving and that he could be discharged as early as Monday.

With one month until Election Day, Trump was eager to project strength despite his illness. The still-infectious president surprised supporters who had gathered outside Walter Reed National Military Medical Center, driving by in a black SUV with the windows rolled up. Secret Service agents inside the vehicle could be seen in masks and other protective gear.

The move capped a weekend of contradictions that fueled confusion about Trump’s health, which has imperiled the leadership of the U.S. government and upended the final stages of the presidential campaign. While Trump’s physician offered a rosy prognosis on his condition, his briefings lacked basic information, including the findings of lung scans, or were quickly muddled by more serious assessments of the president’s health by other officials.

In a short video released by the White House on Sunday, Trump insisted he understood the gravity of the moment. But his actions moments later, by leaving the hospital and sitting inside the SUV with others, suggested otherwise.

“This is insanity,” Dr. James P. Phillips, an attending physician at Walter Reed who is a critic of Trump and his handling of the pandemic. “Every single person in the vehicle during that completely unnecessary presidential ‘drive-by’ just now has to be quarantined for 14 days. They might get sick. They may die.”

“For political theater,” the doctor added. “Commanded by Trump to put their lives at risk for theater.”

White House spokesman Judd Deere said Trump’s trip outside the hospital “was cleared by the medical team as safe to do.” He added that precautions were taken, including using personal protective equipment, to protect Trump as well as White House officials and Secret Service agents.

Joe Biden’s campaign, meanwhile, said the Democratic presidential nominee again tested negative for coronavirus Sunday. The results come five days after Biden spent more than 90 minutes on the debate stage with Trump. Biden, who has taken a far more cautious approach to in-person events, had two negative tests on Friday.

For his part, Trump still faces questions about his health.

His doctors sidestepped questions on Sunday about exactly when Trump’s blood oxygen dropped — an episode they neglected to mention in multiple statements the day before — or whether lung scans showed any damage.

It was the second straight day of obfuscation from a White House already suffering from a credibility crisis. And it raised more doubts about whether the doctors treating the president were sharing accurate, timely

City of Hope-led study details new strategy to address the barriers that keep older adults out of clinical trials

The study examined what has been done and chartered a roadmap to improve equitable access using the best-available scientific literature on barriers to older adult participation in cancer clinical trials.

A City of Hope-led study revealed little effort has been made to improve older adult representation in clinical trials of new cancer drugs, even when the treatment is aimed at a disease that disproportionately affects this age group.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20201001005384/en/

William Dale, M.D., Ph.D., director of the Center for Cancer and Aging Research at City of Hope, the study’s senior author. Photo: City of Hope

“There is currently no incentive to establish real-world effectiveness among older adults. Older adults need a seat at the table,” said Mina Sedrak, M.D., M.S., lead author of the study and deputy director of the Center for Cancer and Aging at City of Hope, a world-renowned independent research and treatment center for cancer, diabetes and other life-threatening diseases.

Two in 5 Americans with cancer are age 70 or older, yet fewer than 25% of patients in cancer clinical trials registered with the Food and Drug Administration are in this age group, Sedrak said.

The study was published in the journal CA: A Cancer Journal for Clinicians on Oct. 1. Researchers reviewed 8,691 studies that evaluated barriers which hindered older adults from participating in cancer trials. Twelve articles defined complex, interrelated problems as root causes, including stringent eligibility criteria, physician concern for toxicity, ageism, transportation and caregiver burden.

Only one study implemented an intervention meant to increase enrollment of older adults in trials – and it was not successful. This finding starkly amplifies the lack of effective strategies to improve participation of this underrepresented group in cancer research.

The researchers report that cancer trials must ask appropriate questions tailored or driven by the needs of older adults with cancer and should measure relevant outcomes. Their call to action applies to all oncologists and primary care providers, not just geriatric oncologists, Sedrak said, adding that patients should advocate for themselves.

“Ask your doctor about clinical trial opportunities when you’re diagnosed with cancer and do your own research because there may be an option that you haven’t heard about. It may benefit you, but perhaps your doctor may not have considered you for the investigational trial,” he said.

William Dale, M.D., Ph.D., the study’s senior author and an oncologic geriatrician at City of Hope, said, “We don’t know enough about treating our largest group of cancer patients. In the midst of the COVID-19 pandemic, when enrollment in trials is lower than ever due to isolation and distancing practices, actively including older adults in clinical trials is incredibly important.” Dale is the Arthur M. Coppola Family Chair in Supportive Care Medicine at City of Hope.

City of Hope is a leader in offering older patients appropriate and personalized cancer care, as exemplified by the fact that Dale and his colleagues co-wrote the American Society of Clinical Oncology’s guidelines

Editorial: Nebraska Medicine must inform patients about the hacker attack details | Editorial

Our wired world unavoidably puts our personal information at potential risk. The points of vulnerability are many: Our home computers. Banks and credit unions. Online retailers. Government agencies.

Indeed, the health care sector has been regularly a target of hackers across the country. Nebraska has had several examples. Malware, brought in by a third-party vendor’s device, struck a CHI Health location in 2019. The year before, a hacker accessed patient information at Boys Town National Research Hospital.

Last week, Nebraska Medicine became the latest health care facility targeted in our state for cyberattack. The assault — described as a “significant information technology system downtime event” — led the hospital to postpone patient appointments, with staff resorting to old-style charting of medical information.

Nebraska Medicine has since regained its footing in terms of service delivery.

“People have done a yeoman’s job in making sure we deliver good patient care,” the hospital’s CEO, Dr. James Linder, told The World-Herald. Nebraska Medicine kept its emergency rooms open and didn’t need to divert patients to other hospitals.

The hospital’s information system retains patients’ electronic medical records.

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D.C. hunger report details pandemic’s effects in city

Nearly 150,000 District residents have filed for unemployment insurance as business closures during the coronavirus pandemic led to reduced hours and layoffs. And many residents have applied for food assistance through the Supplemental Nutrition Assistance Program.

“I’m saddened by the fact that the numbers spiked up,” said George Jones, chief executive of Bread for the City, a nonprofit group that provides food, medical care and legal services to low-income D.C. residents. “But I’m not surprised, because we’ve seen similar spikes in our own food pantry and demand for food there.”

Before the pandemic, Bread for the City served 400 households in the District on its busiest days, Jones said. Now, the organization is distributing food to 1,000 households a day. The Capital Area Food Bank’s nonprofit partner network, which includes Bread for the City and serves the Greater Washington region, has seen increases between 30 and 400 percent, according to a spokeswoman for the food bank.

The D.C. report released Tuesday comes months after the Capital Area Food Bank’s hunger report from July, which projected an increase of up to 60 percent in food insecurity across the region this year. That report said the pandemic would push up to 250,000 people into hunger in the District, Montgomery and Prince George’s counties in Maryland, and Arlington, Fairfax and Prince William counties and the city of Alexandria in Virginia.

The pandemic has exacerbated food insecurity in communities of color, data shows. The Office of Planning report refers to a survey from April that found that Black households in the District were 13.5 times more likely to report that they sometimes did not have enough food to eat than White households in the city.

And Latino households were 6.5 times more likely to report they sometimes did not have enough food to eat than White households. The projected increase in hunger is consistent with what the Capital Area Food Bank found for the Washington region.

“This new reality magnifies the urgency of achieving true health equity in the District, with every resident having meaningful access to healthy, affordable, and culturally appropriate food,” Ona Balkus, the food policy director at the D.C. Office of Planning, said in a news release.

The report recommends increasing healthy food options in Ward 7 and Ward 8, which are the District’s poorest wards. Each has more than 70,000 residents, but Ward 7 has just two full-service grocery stores and Ward 8 has one, said Calvin Smith, the chairman of the Ward 8 Health Council.

“Because the median income is between $30,000 and $35,000 a year in Ward 8, there is not a great business case, as they tell us, for supermarkets to make their level of investments,” Smith said.

Hunger in the city appears to be growing most in Ward 7 and 8, which signals that other wards in the city are probably better managing the economic fallout of the pandemic.

The report also references a Feeding America report that estimates the child food insecurity rate will be

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That is the primary reminiscence of my life, the evening the police took us and being crushed by employees at MacLaren Corridor, making me sleep on the ground, segregating me from my brothers, no food or water. The authors recommend developing international standards in medical training and health care delivery, which has the potential of improving the standard of health care around the world.

In an article by Snyder et al. (2011), countries who continue to just accept patients from different lands for costly companies run the chance of either pricing out poorer citizens, or making a second tier of medical care in these countries. Somewhat than be an imposing and daunting challenge to grasp, the end result can be improvement of danger management programs to guide the supply of health care.

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