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CDC launches new plan to tackle antibiotic-resistant infections

Oct. 9 (UPI) — U.S. Centers for Disease Control and Prevention officials announced Friday what they describe as a “national action plan” to fight antibiotic-resistant infections.

The bacteria that cause these diseases cannot be treated by currently available antibiotic drugs, meaning patients who suffer from them may experience severe health complications or even death.

Antibiotic-resistant bacteria have been linked with an estimated 35,000 deaths across the United States annually, and treating them costs the nation’s healthcare system an estimated $4.8 billion per year, according to the CDC.

“The National Action Plan for Combating Antibiotic-Resistant Bacteria gives the U.S. government its marching orders for the next five years to accelerate the nation’s efforts to stop the spread of antibiotic-resistant bugs,” the agency said in a statement.

The CDC did not provide details on the cost of the plan, but reports suggest that, in the past, more than $150 million has been allocated annually by the agency to fight antibiotic-resistant threats in all 50 states and Puerto Rico. It is a follow-up to a similar initiative launched in 2015, the agency said.

Examples of common antibiotic-resistant infections include staph — such as methicillin-resistant staphylococcus aureus, or MRSA — as well as sepsis and Clostridioides difficile, or C. diff.

The emergence of these bacteria has been linked with the overuse of antibiotics. About 30% of all antibiotics are administered unnecessarily, according to the CDC.

Roughly 2.8 million Americans are diagnosed with drug-resistant infections annually, and disease like MRSA can spread in public places, while sepsis and C. diff typically circulate in healthcare facilities, the agency said.

The goal of the action plan is to reduce by 2025 the prevalence of healthcare-associated antibiotic-resistant infections like sepsis and C. diff by 20% and community-acquired antibiotic-resistant infections like MRSA by 10%.

To do so, the agency plans to expand its antibiotic resistance lab network internationally to identify and respond to emerging disease threats “in every corner of the world.”

Domestically, the initiative will support investments in state and local health departments across the country, providing up to $2.5 million per agency to “detect, contain and prevent antibiotic-resistant infections.”

The plan also includes the establishment of a “Center of Excellence for Whole Genome Sequencing,” which identifies the DNA make-up of bacteria, at the National Institutes of Health’s National Center for Biotechnology Information to gain better understanding of how these diseases are transmitted.

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Doctors urged to tackle malnutrition in obesity

A recent editorial calls on doctors to address the underrecognized problem of malnutrition among individuals with obesity to help prevent early death from cardiovascular events.

A study has found that malnutrition is common among people with acute coronary syndrome, which is the sudden reduction of blood flow to the heart that causes angina or a heart attack.

The researchers — at the University Hospital Álvaro Cunqueiro in Vigo, Spain — found that malnutrition in these individuals was an independent risk factor for all-cause mortality and major cardiovascular events, such as stroke or another heart attack.

Surprisingly, they found that malnutrition was common even among those with overweight or obesity.

The results appear in the Journal of the American College of Cardiology.

In an accompanying editorial, two cardiologists write that physicians commonly perceive malnutrition to be a problem that only affects people who are “undernourished” — in other words, underweight.

In fact, individuals with overweight or obesity are often malnourished as a result of their low intake of micronutrients and the poor quality of the foods that they eat.

“Malnutrition is a largely underrecognized and undertreated condition in patients with increased body mass index, as increased abdominal girth is too often mistaken for overnutrition rather than undernutrition,” says Dr. Andrew Freeman, director of cardiovascular prevention and wellness at National Jewish Health in Denver, CO.

Dr. Freeman co-authored the editorial with Dr. Monica Aggarwal, who is an associate professor of medicine at the University of Florida in Gainesville.

“It’s important to dispel the thought that weight is correlated with food quality and that [patients with obesity] are not at risk of malnutrition,” says Dr. Freeman.

The World Health Organization (WHO) estimate that 462 million adults have underweight worldwide, whereas 1.9 billion have overweight or obesity. However, they note that the term malnutrition can apply to both of these groups.

The researchers in Spain conducted a retrospective analysis of 5,062 people admitted to the University Hospital of Vigo with acute coronary syndrome.

They calculated the body mass index (BMI) of each person and scored their nutritional status using three standard measures: the Controlling Nutritional Status score, the Nutritional Risk Index, and the Prognostic Nutritional Index.

These measures use different combinations of values, such as BMI and blood levels of albumin, white blood cells, and cholesterol, to estimate the quality of the nutrition that a person is receiving.

According to these three measures, between 8.9% and 39.5% of all of the participants — depending on the specific measure — were moderately or severely malnourished.

Although those whose BMI labeled them as having underweight were the most likely to be moderately or severely malnourished, between 8.4% and 36.7% of those whose BMI suggested they had overweight or obesity fell into these categories.

Moreover, up to 57.8% of those with overweight or obesity had some degree of malnutrition, again depending on the index used.

During the median follow-up period of 3.6 years, 20.7% of the participants had a major cardiovascular event, and 16.4% of them