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Minimally invasive procedure may free Type 2 diabetics from insulin

A small study suggests that a new procedure that treats part of the intestine just beyond the stomach may allow people with type 2 diabetes to safely stop taking insulin.

The procedure — which resurfaces the duodenum — was combined with a popular kind of diabetes medication called GLP-1 receptor agonists — such as Victoza, Trulicity, Ozempic — and counseling on lifestyle factors, such as nutrition and physical activity.

Six months after treatments began, three-quarters of participants taking insulin no longer needed it. The amount of fat stored in their livers dropped from 8% to less than 5%.

“The duodenum harbors a broad potential for the treatment of type 2 diabetes and this combination treatment could be a game-changing approach in the treatment of type 2 diabetes and the metabolic syndrome,” said lead researcher Dr. Suzanne Meiring, of Amsterdam University Medical Center in the Netherlands.

This preliminary study included 16 patients, all of whom underwent Duodenal Mucosal Resurfacing, or DMR. There was no placebo group or medication-only group for comparison. The study was funded by Fractyl Laboratories, which developed the procedure.

DMR is a minimally invasive procedure that relies on an endoscope — a narrow, flexible tube containing a light and video camera that lets your doctor see inside the body. The endoscope may also carry special tools for treatment. The tube is threaded down the throat into the digestive system.

In DMR, the endoscope is guided to the duodenum, where doctors then resurface, or ablate, its lining. Meiring said it’s not yet clear why the procedure works.

“We think the effects result from a combination of changes that occur when the duodenal mucosa is ablated and rejuvenated,” she said. “We think that changes in hormonal signaling, including the gut hormone GLP-1, bile acid compositions and the microbiome play an important role.”

The 16 participants had type 2 diabetes for an average 11 years. On average, they had been on insulin just under three years. None had taken a GLP-1 receptor agonist before the study.

At the outset, their average A1C levels — an estimate of blood sugar levels over two to three months — were under 8%. After 12 months, the average fell to 6.7%. For most adults, the American Diabetes Association recommends aiming for an A1C below 7%.

After the DMR procedure, patients were given a specific diet for two weeks. After that, they began taking the GLP-1 receptor agonist medication.

Meiring said researchers added the drug because it also targets the duodenum. They hoped it would boost the effects of DMR, “possibly even causing a synergistic effect,” she said.

She said she doesn’t think the positive effects in this study stem from just the drug treatment. Other studies have shown that about 10% of people who start GLP-1 therapy are able to get off insulin, Meiring said. In this study, 75% of those taking insulin were able to stop.

Participants who weren’t insulin-free after 12 months needed only about half the insulin they required before the procedure.

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Millions of lives are saved yearly due to one animal’s, results to both a drug or new form of surgery, and I imagine instead of believing that an animal’s life was a waste; I view it as an alternative as the subsequent step in bettering individuals’s lives for tons of of years to come back.

Many people turn to CAM because of opposed effects of pharmaceutical medication. I did not know that the people earlier than me had animals with mange & knew in regards to the fleas, so I shrugged it off & got Entrance Line & now they are all dropping fur & have red spots, they’re warm to the touch.

Dengue virus is now attacking the inner system of the sufferer causing hemorrhagic results, like bleeding and low rely of blood platelets. Dizziness, muscle and stomach ache and head ache are among the unwanted side effects of these medicines. I would like to get in touch with you or the Dr to seek out out extra concerning the remedy as i wish to go to you and the Dr. thank you once once more on your time and help.

He was administered with blood transfusion however my mother requested that she be allowed to let him drink the boiled juice of Tawa-tawa. These are all body painkiller medicines. For many people, the blood thickens as the body makes an attempt to deal with the intense warmth, and nosebleeds and swollen ankles are frequent for those unused to the Greek summer time.

However it’s a vast branch of medicine coping with the prevention,diagnosis,treatment of the conditions,ailments and disorders of the oral cavity and the maxillofacial area and its associated constructions. Earlier than 1992 when screening for hepatitis C was not yet around, people who acquired blood transfusion could have gotten this virus.…

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They have an inclination to look other than the information that animals have given millions around the globe a brand new outlook on life, and would slightly see solely the negative unwanted side effects of animal testing which far outweighs the constructive things animal testing has contributed to the medical world.

Many people flip to CAM due to antagonistic results of pharmaceutical medication. I didn’t know that the people before me had animals with mange & knew about the fleas, so I shrugged it off & bought Entrance Line & now they are all dropping fur & have pink spots, they are heat to touch.

Stretch marks removing: Biotin makes your pores and skin healthier and helps eliminate stretch marks. We can’t count on support from the federal government of the Philippines because the medical advisers are schooled in conventional medicine who ignore or scorn the free radical theories of illness.

On the whole, medieval medicine was a mixture of historic physiology, empirical data of the consequences of some medicine, medical superstition and the charlatanism of apothecaries. Drugs could also be categorised on the basis of signs or diseases during which they’re used.

Olives are healthy for animals in addition to humans they usually made the soil excellent for farming. Scientific research utilizing animals are considerably slowed with new medicine just being rehashed as new ones (and then selling it for tons of money). It’s time that we attain for natural well being than the pharma drugs which can be killing the world.…