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Lipocine Announces Presentations at the 21st Annual Fall Meeting of the Sexual Medicine Society of North America

SALT LAKE CITY, Oct. 14, 2020 /PRNewswire/ — Lipocine Inc. (NASDAQ: LPCN), a clinical-stage biopharmaceutical company focused on metabolic and endocrine disorders, today announced it will present results from studies suggesting that low testosterone levels may play an important role on the clinical outcomes of COVID-19 in men as well as the safety and efficacy of TLANDO™, an oral testosterone replacement therapy without a dose titration requirement, at the 21st Annual Fall Scientific Meeting of the Sexual Medicine Society of North America (“SMSNA”). Lipocine will outline the possible mechanisms and clinical evidence that suggests men with low testosterone have poor COVID-19 outcomes, and the rationale of using an oral testosterone therapy for men with COVID-19. Results from the previously completed dose validation (“DV”) study of a fixed dose TLANDO in hypogonadal males will also be presented at the meeting.  The presentations will take place virtually on November 9, 2020 from 7:00 p.m.9:00 p.m. EST during Session 2 (Androgens and Ejaculation/Orgasm Disorders). 

https://www.smsna.org/V1/2020/program/scientific-program?where_person=44
https://www.smsna.org/V1/2020/program/scientific-program?where_person=42

“We know that while COVID-19 infection rates are comparable between men and women, men are developing severe symptoms and dying at a significant higher rate than women. Furthermore, men with comorbidities commonly associated with lower testosterone are at greater risk for severe disease and death,” said Dr. Mahesh Patel, Chairman, President and CEO of Lipocine Inc.  “The presentation on COVID-19 highlight key clinical evidences suggesting that low testosterone levels may play an important role on the clinical outcomes of COVID-19 in men. Based on the published data, the use of oral testosterone with the goal of achieving physiological testosterone levels should be evaluated in clinical trials of COVID-19.”

Dr. Anthony DelConte, Chief Medical Director of Lipocine further stated, “TLANDO will be the first oral testosterone for treatment hypogonadism without titration requirement. It is expected to be easy to prescribe and use.” Dr. DelConte added, “The SMSNA presentation on TLANDO highlights the key safety and efficacy data from multiple clinical studies supporting TLANDO’s ability to effectively restore testosterone levels in hypogonadal men without need for any dose adjustment.”

Is Oral Testosterone a Potential Treatment for COVID-19 in Men? (Benjamin J. Bruno et al)

The authors performed a literature search to understand the possible mechanisms and clinical evidence concerning testosterone levels in COVID-19 patients.  A recent clinical study investigating testosterone levels in men with COVID-19 found 80% of men who died due to COVID-19 had low total or bioavailable testosterone levels at the time of hospital admission. Those with severe Acute Respiratory Distress Syndrome (“ARDS”) had acutely depressed total testosterone compared to patients who did not exhibit severe ARDS. The mean total testosterone levels for men who required invasive ventilation was 29 ng/dL (normal range ~300-1100 ng/dL), whereas those who were discharged from the ICU had mean total T of 254 ng/dL at the time of ICU admission.

In comparison to other routes of testosterone administration, oral testosterone therapy may be the most convenient and suitable for acute treatment of COVID-19 in

Biden, Harris Split on Coronavirus Vaccine at Vice Presidential Debate | America 2020

Vice President Mike Pence and Sen. Kamala Harris on Wednesday kicked off the first and only vice presidential debate by highlighting their divide over the coronavirus pandemic.

Surveys have shown a significant number of people would not be willing to take a coronavirus vaccine. Harris indicated she would be eager to get a vaccine if it were recommended by experts.

“If the public health professionals, if Dr. Fauci, if the doctors tell us that we should take it, I’ll be the first in line to take it, absolutely,” Harris said. “But if Donald Trump tells us that we should take it, I’m not taking it.”

Photos: Daily Life, Disrupted

TOPSHOT - A passenger in an outfit (R) poses for a picture as a security guard wearing a facemask as a preventive measure against the Covid-19 coronavirus stands nearby on a last century-style boat, featuring a theatrical drama set between the 1920s and 1930s in Wuhan, in Chinas central Hubei province on September 27, 2020. (Photo by Hector RETAMAL / AFP) (Photo by HECTOR RETAMAL/AFP via Getty Images)

Pence accused Harris of sowing doubt over the vaccine.

“The fact that you continue to undermine public confidence in a vaccine, if the vaccine emerges during the Trump administration, I think is unconscionable,” Pence said.

Harris, like her running mate Joe Biden during the previous presidential debate, painted the Trump administration as not having a plan for the pandemic, which has infected over 7.5 million people in the U.S. and killed more than 211,000.

“The American people have witnessed what is the greatest failure of any presidential administration in the history of our country,” Harris said.

The seven-day average for new coronavirus infections is over 43,000 cases, according to government statistics compiled by USAFacts. That average for fatalities is about 680 deaths. While cases and deaths are below what they were during their previous peaks, they are still elevated.

(Courtesy of USAFacts)

(Courtesy of USAFacts)

Pence said that it is a “great disservice to the sacrifices the American people have made” to say efforts over the last eight months haven’t worked.

Pence, in response to a question from moderator Susan Page, also defended the event in the Rose Garden 11 days ago where social distancing was not observed and very few were seen in masks. President Donald Trump and the first lady tested positive for the coronavirus following the event.

“Many of the people who were at that event, Susan, actually were tested for coronavirus, and it was an outdoor event, which all of our scientists regularly and routinely advise,” Pence said.

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The Compounding Effect of Colon Cancer Disparities in America

In August, acclaimed actor Chadwick Boseman tragically passed away at age 43 after a four-year battle with colon cancer. Boseman played the role of Black Panther as well as several African American historical icons, some of which he filmed while quietly undergoing cancer treatment.

(Getty Images)

Colorectal cancer, which is characterized by the uncontrolled growth of abnormal cells in the colon or rectum, accounts for 8.2% of all new cancer cases and is the second leading cause of cancer death in the United States. Colon cancer also disproportionately affects communities of color and economically marginalized populations.

As part of U.S. News’ ongoing series on health equity, U.S. News data analysts took a closer look at disparities in colon cancer and found stark differences in who was diagnosed, at what stage, and how they fared. Black, Hispanic and low socioeconomic status patients were less likely to be screened, more likely to be admitted for an emergent procedure, and had an increased risk of mortality and shorter overall survival time compared with wealthier, white patients. This analysis, combined with an investigation of peer-reviewed literature and interviews with clinical experts, revealed the pivotal role that preventive care has in driving some of these disparities.

Factors that contribute to cancer disparities across racial and socioeconomic lines are complex and interrelated. Socioeconomic status here refers to individuals who are simultaneously enrolled in both Medicare and Medicaid. In 2018 there were 12.2 million dual eligible beneficiaries, 60% of whom have multiple chronic conditions, according to the Centers for Medicare & Medicaid Services.

Many dual eligible patients also experience a higher burden of social risk factors, such as poverty and limited access to community resources, and need ongoing long-term care services and support. The racial breakdown of Medicare beneficiaries by dual eligibility status in Table 1 shows that both Black and Hispanic patients are overly represented in the dual eligible portion of the population, when compared with the breakdown of all eligible beneficiaries. For example, despite making up only 11% of all Medicare beneficiaries, Black patients are 20% of dual eligible beneficiaries. This trend is reversed for white patients, who comprise 80% of all Medicare beneficiaries but just 62% of dual eligible beneficiaries. These statistics indicate that Black and Hispanic Medicare beneficiaries are more likely to be dual eligible than their white counterparts.

Among Medicare patients with colon cancer who underwent surgery, Black and Hispanic patients experienced longer hospital stays, and they were more likely to be readmitted to the hospital within 30 days of the procedure compared with their white counterparts, after accounting for comorbidities. While Hispanic patients had an increased risk of mortality within 30 days of the procedure, there was a reduced risk of death among Black patients, when compared with white patients. Figure 1 demonstrates the risk of these outcomes by race and socioeconomic status. Within each race and ethnic category, we see that dual eligible patients in fact consistently experience a higher risk of poor outcomes after undergoing colon cancer surgery.

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Trump, Biden Butt Heads on U.S. Coronavirus Response, Vaccines and Mask-Wearing | America 2020

President Donald Trump and former Vice President Joe Biden unsurprisingly presented vastly different views of the status of the coronavirus pandemic in the U.S. during the first general election debate Tuesday night.

Trump attempted to blame China for the outbreak, saying that his administration has done a “great job” responding to the pandemic. He claimed that if Biden were in charge, millions instead of hundreds of thousands would have died across the nation.

“We’ve done a great job,” Trump said. “But I tell you, Joe, you could never have done the job we’ve done. You don’t have it in your blood.”

Biden, meanwhile, tried to paint Trump as an uncaring leader with no plan.

“Forty thousand people a day are contracting [COVID-19]. In addition to that, about between 750 and 1,000 people a day are dying,” Biden said. “When he was presented with that number he said, ‘it is what it is.’ Well, it is what it is because you are who you are.”

Biden’s numbers are correct according to government statistics compiled by USAFacts. While cases and deaths are below what they were during their previous peaks, they are still elevated.

(USAFacts)

(USAFacts)

Like much of the debate, the candidates frequently talked over each other and laced their answers with insults and misstatements.

The two clashed on vaccines and mask wearing, with Trump saying that vaccine development is a “very political thing.” The president acknowledged his disagreements with scientists in his own administration, including his past clash with Robert Redfield, director of the Centers for Disease Control and Prevention, over the vaccine timelines and the effectiveness of wearing face coverings.

Trump repeated his claim that a vaccine announcement could come in just weeks, though public health experts have said it will take some time to be made available to the public. He also said it would be delivered to the public “right away.”

Biden appeared to address viewers as he countered: “Do you believe for a moment what he’s telling you, in light of all the lies he’s told you about the whole issue relating to [COVID-19]?”

The former vice president cited comments Trump made to journalist Bob Woodward back in February that the virus is “deadly stuff” and “more deadly than even your strenuous flu.” Trump has repeatedly tried to minimize the backlash he received over his statements to Woodward related to the pandemic.

Trump was also questioned on his view of wearing masks to help prevent the spread of the virus. He said he thinks masks are OK, adding that he puts one on when he feels he needs it. However, Trump earlier this month claimed that masks are a “mixed bag.”

Biden said masks “make a big difference,” citing statements from Redfield who has said they are “the most important, powerful public health tool we have.”

The U.S. topped 7 million cases of the coronavirus and 200,000 deaths last week. It’s the most reported infections and fatalities of any country. Public health officials have

Ley Lines In North And South America

I feel that is cruel and unfair to animals this king of factor must be unlawful these poor creatures are suffering feeling pain and can’t do anything to cease it.people are silly their having fun with wearing their making and fragrance and they do not realize that animals are being tested and dying just to allow them to look and scent good.

Believe it or not, there used to be a time when the leaves that had the shape of the liver have been used for the remedy of liver ailments. It is doable to take Prednisone by the mouth (by way of a handy pill type), injection straight by way of the skin and into the bloodstream, or by an IV (intravenous) drip as part of a long run remedy choice.

Dengue virus is now attacking the inside system of the sufferer inflicting hemorrhagic results, like bleeding and low rely of blood platelets. Dizziness, muscle and stomach pain and head ache are a number of the unintended effects of these medicines. I would like to get in touch with you or the Dr to search out out extra concerning the remedy as i want to visit you and the Dr. thank you once again to your time and support.

Blood-letting was believed to drive out evil spirits; therefore, the procedure was performed by a priest, which was additionally a physician at that time. That’s, the doctor can’t divulge if someone is contaminated with hepa B virus or not to just anyone, except of course to the patient or proxy.

I sure do agree, i hate people who abuse animals.i think we must always all treat animals like we deal with humans. They’re less active than the medicine of first era towards gram positive bacteria, but they’ve the power to cross the blood-brain barrier.…

The United States Of America Ought to Take Care Of Its Personal First

Social health, along with mental and bodily health, is without doubt one of the key elements to find out the overall well-being of a person. Within the United States, $ninety nine billion is spent on direct therapy for those with psychological health points (Florida Council for Neighborhood Mental Health). Many factors can weaken the body’s resistance towards germs, including climate, food additives, anger, worry, bad thoughts, insincerity, stress, age, unhealthy setting, and even supernatural spirits.

Whereas it’s true to say that health care is the prevention, treatment and management of illness, and the preservation of psychological and physical nicely-being, by the providers offered by the medical, nursing and allied health professions, health-related behaviour is influenced by our personal values, that are decided by upbringing, by instance, by expertise, by the corporate one keeps, by the persuasive energy of promoting (often a power of behaviour that can hurt health), and by effective health education.

Some people will swear that motorbike using promotes healthy mind growth. The benchmarks still restrict visits and lifetime monetary benefits, which doesn’t happen for medical or surgical benefits (Nguyen). The reason for the score is that for adults with mental health, Florida ranked 25 out of fifty one; for youngsters, 29 out of 51, which exhibits that youngsters in Florida fare worse than adults relating to receiving mental health providers (Nguyen).

On the similar time there is a great demand on having EHRs simply accessible for health care providers. To meet the expectations of the Native People, health care employees want to understand and integrate into remedy and procedures the beliefs of the patients’ tribes.

Onions, whether raw or cooked, (uncooked has extra diet), are a healthy food with healthy advantages. Nevertheless, until we’re healthy, till our citizens should not have to beg for meals, then I need our efforts targeting our personal needy. A coronary heart that’s healthy and nicely taken care off is extra able to deal with demands and stress that’s put on the physique.…

The United States Of America Ought to Take Care Of Its Own First

A listing of the top 10 healthiest foods could look like a come-on. In the event you merely cannot address a healthy diet, exercise and emotional management, however genuinely favor to eat junk meals, be permanently drunk, be under constant stress, and be disliked by others, then get pleasure from your life while it lasts, however perceive that the commerce-off is that it’s going to probably not last long.

Nevertheless, many people are embracing the attitudes to healthy life, whereas some companies are busy raking in the income. Many cancer sufferers need to tolerate a number of pain throughout their treatment. These super meals are perfect for coronary heart healthy, low fats cooking and most fit completely right into a low carb way of life as properly.

The Anti-Kickback statute creates a protecting umbrella, a zone in which patients are protected in order that the best health care is offered. Generally patients have fears of taking medicines they aren’t used to, find out if the affected person has any concern of overdose or dependancy to pain medicine, whether or not ibuprofen or morphine.

At the identical time there’s a great demand on having EHRs easily accessible for health care providers. To meet the expectations of the Native Individuals, health care employees need to grasp and combine into treatment and procedures the beliefs of the patients’ tribes.

Even literate, properly-educated people sometimes have misguided views about what makes or keeps them healthy, typically believing that common every day train, common bowel actions, or a particular dietary regime will alone suffice to preserve their good health.…

The United States Of America Should Take Care Of Its Own First

There may be some basic physiology that results how stress impacts ones health. College of Cincinnati and Dr. Eugene Saenger, radiologist and an professional in nuclear medication whose analysis contributed to the establishment of radiation security requirements for sufferers and medical personnel , performed experiments from 1960-1971.

Kaiser Permanente shares pamphlets of knowledge with their sufferers, which instructs them to make healthier meals selections. Truly, CBD comprises a non-psychotic chemical compound which presents a variety of benefits for cancer patients. For many individuals, the blood thickens as the physique attempts to cope with the extreme heat, and nosebleeds and swollen ankles are common for those unused to the Greek summer.

Fritz Redlich, a psychoanalyst, tried to know Hitler’s motivations and merciless actions, but ended with the conclusion that Hitler was simply an evil man” and the psychological excuses that folks theorized were simply insanity defenses; yet to truly be categorized as evil, one would have to commit an evil deed each day, which Hitler didn’t do. Adolf Hitler was not evil, since evil individuals don’t exist, but he needed to have a robust motive to risk what he risked, which was his life.

Patients might try to distract themselves from the ache by crying or even laughing. The important thing areas of potential threat beneath the Federal Anti-Kickback statute additionally come up from pharmaceutical manufacturer relationships with three groups: purchasers, physicians or different health care professionals, and sales brokers.

Whereas it is true to say that health care is the prevention, remedy and management of sickness, and the preservation of mental and physical effectively-being, via the services supplied by the medical, nursing and allied health professions, health-related behaviour is influenced by our personal values, that are determined by upbringing, by instance, by expertise, by the company one retains, by the persuasive energy of promoting (typically a drive of behaviour that may harm health), and by effective health training.…

Ley Strains In North And South America

Animal cruelty is improper however what about all those folks we have now locked up as a result of they’ve done one thing incorrect we should use them for our resurch in stead of animals. Alternatively when medicine failed and the affected person died, their physique was washed in anointed in scented oil before being laid to rest.

Since the external indicators are the identical, we can assume that animals feel the identical pain that we as humans really feel. Typically sufferers have fears of taking medications they are not used to, find out if the affected person has any fear of overdose or addiction to ache medication, whether or not ibuprofen or morphine.

Actually they appeared down upon different people for utilizing it. As a substitute after they went to bathe they rubbed oil throughout their bodies after which scraped it off, carrying away all the dust and grime with it and leaving the pores and skin silky and moisturized; this methodology was really healthier than the crude soaps of the time.

Used in night vision units to watch animals or people utilizing the phenomenon called infrared illumination. For instance, information of and isolation of the properties of olive oil (calcium elonolate) for therapy had been mendacity within the cabinets of Upjhon company for 100 years but couldn’t develop it right into a drug because it couldn’t machine a delivery system.

They tend to look other than the info that animals have given tens of millions world wide a brand new outlook on life, and would reasonably see only the destructive unwanted side effects of animal testing which far outweighs the positive issues animal testing has contributed to the medical world.…