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Pain Pill Abuse Higher in Adolescent CBD Oil Users

Adolescent users of cannabidiol (CBD) oil are far more likely to engage in risk-taking behaviors ― such as illegally taking prescription pain medications ― than peers who don’t use CBD, new research indicates.

The study, which included data on 200 youths aged 12 to 23 years, also suggests that 4 in 10 use CBD oil products. Users also reported experiencing increased anxiety over the prior 6 months, but the researchers couldn’t pinpoint whether CBD oil, which is marketed for anxiety relief, might contribute to participants’ anxiety levels.



Nicole Cumbo

“A lot of kids don’t talk to their clinicians about CBD” use, said study author Nicole Cumbo, BS, a third-year medical student at Penn State Milton S. Hershey Medical Center in Hershey, Pennsylvania.

“It’s important to ask kids if they’re using CBD, along with vaping and marijuana use, because it could be causing them more problems than it helps,” Cumbo told Medscape Medical News. “Monitoring for dangerous behaviors in their social history is important. Since we were able to see a correlation between risk-taking behaviors, we should ask kids about risk-taking behaviors as well.”

Touted as a panacea for conditions ranging from insomnia to muscle aches to low mood and more, CBD oil products have become ubiquitous across the United States, Cumbo noted. “Even if you go to a gas station, you see it,” she said. “It’s growing prevalence is apparent, but we weren’t sure what we’d see in our pediatric population.”

Cumbo and colleagues administered questionnaires to adolescents who presented for medical care to a level 1 pediatric trauma center/emergency department affiliated with a children’s hospital in central Pennsylvania. The questionnaire asked about demographics, risk-taking behaviors, and use of CBD oil products. The survey also asked participants about clinical symptoms experienced over the prior 6 months, along with their views on the perceived benefits of using CBD oil.

The average age of the participants was 17.6 years, and 63% were female. Forty percent reported CBD oil use. Compared to nonusers, among those who used CBD oil, there was significantly greater use of prescription medications without a prescription (19% vs 6%; P = .002), as well as greater use of cigarettes (40% vs 8%; P < .0001), chewing tobacco (18% vs 1%; P < .0001), and cigars (30% vs 3%; P < .0001).

No significant differences were found between CBD users and nonusers in symptoms such as chest pain, racing heart, difficulty breathing/cough, dizziness, abdominal discomfort, nausea/vomiting, headache, tremors, sleep disturbances, or dehydration over the prior 6 months.

However, those who used CBD were more likely to report experiencing an increase in anxiety over the prior 6 months (66% vs 47%; P = .009).

Regarding their perceived beliefs about CBD oil, 69% said it is “safer than other drugs,” 33% said it’s “just for fun,” and 48% said it can “help treat my medical illness.” Participants reported that myths about CBD oil include the notions that it’s a gateway drug and that it’s addictive.

“I think there’s a disconnect in

FDA Panel: All Thumbs Down for Amphetamine Product Meant to Deter Abuse

An FDA advisory committee voted unanimously Thursday that the risks of a novel amphetamine designed to deter abuse outweighed the benefits, concluding it may in fact be misused and could be even more dangerous than conventional stimulant medications for attention deficit-hyperactivity disorder (ADHD).

The panel also voted 19-2, with two abstentions, that drugmaker Arbor Pharmaceuticals did not adequately address the safety of AR19 (amphetamine sulfate), with many panelists noting that the drug appeared safe when administered orally, but that high levels of talc and polyethylene oxide in the drug’s composition could be toxic if taken through snorting or injection.

The joint meeting of the Psychopharmacologic Drugs Advisory Committee and the Drug Safety and Risk Management Advisory Committee also concluded with a 15-8 vote that Arbor did not adequately demonstrate AR19 would deter intravenous use, and voted 19-4 that it did not adequately demonstrate it would deter intranasal use.

In fact, the product’s ability to deter manipulation was “slim to nonexistent,” while the risks of the excipients were “too high and uncharacterized” to establish safety, said panel member Steven B. Meisel, PharmD, of M Health Fairview in Minneapolis.

The immediate release, pellets-in-capsule drug contains the same active ingredient as Arbor Pharmaceuticals’ currently-approved ADHD amphetamine Evekeo, but with physical and chemical barriers to deter non-oral intake.

Many panelists agreed that an abuse-deterrent amphetamine would be beneficial. But the likely impact on abuse would be relatively small, they said.

Moreover, the vast majority of amphetamine abuse occurs through the oral route, and non-oral misuse often starts with oral misuse, said Sonia Hernandez-Diaz, MD, MPH, DrPH, of the Harvard T.H. Chan School of Public Health in Boston. AR19 was not proposed to deter oral abuse.

“I think this approach would make sense if manipulation were working very well and [AR19] was the only amphetamine on the market,” Hernandez-Diaz added.

The conclusions of the panel may come as no surprise after the skeptical review FDA staff gave the product received in advance of Thursday’s meeting. Agency scientists wrote that it was feasible to extract a minimum reinforcing dose (10 mg amphetamine per mL over 1 minute) suitable for injection when using higher doses of AR19.

Arbor’s own studies aimed at determining whether manipulation could allow the drug to be snorted showed that ordinary household tools couldn’t significantly reduce particle size. But with modifications, one tool was able to crush AR19 particles down to snortable size.

Philip Posner, PhD, the panel’s patient representative from Gainesville, Florida, voted yes to both the intranasal and intravenous deference questions. He argued the evidence showed users would be far less likely to abuse AR19 compared to other stimulants on the market.

“When you compare this product with everything else that’s on the market, or that students can get elsewhere, I think they’re going to take the easy way out,” Posner said. “They’re not going to go through the excess work of emptying capsules, crushing tablets, and putting them in powder form to snort.”

That view failed to persuade Karim Anton

‘Abuse Deterrent’ ADHD Tx May Face Uphill Approval Path

An abuse-deterrent stimulant product for attention deficit-hyperactivity disorder (ADHD) got a skeptical review from FDA technical staff ahead of an advisory committee meeting later this week.

AR19 is an oral amphetamine sulfate immediate-release capsule formulated to reduce non-oral abuse. The drug, developed by Arbor Pharmaceuticals, will go before the Psychopharmacologic Drugs Advisory Committee (PDAC) and the Drug Safety and Risk Management (DSaRM) Advisory Committee on Thursday.

The main question looming over AR19 is whether it will indeed deter intranasal and IV abuse through its novel formulation. In briefing documents prepared for panel members, FDA staff suggested they weren’t persuaded by the company’s studies.

Non-medical use of prescription stimulants has remained relatively stable since 2010 and, in 2018, 2% of the U.S. population was misusing stimulants, according to the briefing documents. Young adults are more likely than adults of other ages to misuse stimulants, and the vast majority of misuse occurs orally.

However, based on the immediate-release properties of AR19 capsules, the drug was not intended to and “will not deter abuse by the oral route,” the agency staff stated.

Intranasally, AR19 “did not provide convincing evidence” of abuse-deterred effects compared to 10-mg amphetamine sulfate in a human abuse potential (HAP) study, wrote Tiffany R. Farchione, MD, acting deputy director of the psychiatry division of the FDA Office of Neuroscience, in the briefing documents.

The drug failed to demonstrate a 10% reduction in the reinforcing properties outlined in the HAP study. However, that study was later invalidated because the drugmaker did not prespecify a protocol that removed outlier subjects, the agency staff stated.

Regardless, in a post-hoc analysis conducted by the FDA that excluded outliers, “drug liking” — a measure of abuse liability — was not significantly different between groups either.

In syringeability studies submitted in the application, it was feasible to extract at least 10 mg of amphetamine sulfate per liter when using the higher doses of AR19 (20 mg and 40 mg), which constitutes the minimum reinforcing dose, according to the briefing documents.

Although there were no safety concerns identified with the administration of AR19 when taken orally, the formulation of the drug has been linked with toxicities, such as hemolysis and thrombotic microangiopathy, when manipulated for unintended routes of administration, the agency stated.

Arbor Pharmaceuticals seeks approval and labeling of AR19 as an Abuse-Deterrent Opioid because there is no established pathway for developing abuse-deterrent stimulants.

“The patterns of misuse and abuse, morbidity, and mortality associated with prescription stimulants are different from those associated with prescription opioids, and the [FDA] has not determined that prescription stimulant products warrant the same regulatory approach as opioid analgesics with regard to [abuse-deterrent formulations],” Farchione wrote.

She noted that the FDA has also “expressed concerns” that the term “abuse deterrent” is often misinterpreted to mean a drug carries a lower risk of addiction.

AR19 contains the same active ingredient as Evekeo (amphetamine sulfate), Arbor Pharmaceuticals’ FDA-approved ADHD treatment. AR19 has been shown to reduce symptoms in adults with ADHD. The proposed dosing ranges

Paris Hilton calls for Utah boarding school’s closure following her abuse allegations, starts petition

Paris Hilton is calling for the Provo Canyon School (PCS) — where the socialite alleges she was abused while she was enrolled as a teen — to be shut down.

The former “Simple Life” star shared never-before-heard details of what she allegedly endured in her new documentary “This is Paris,” as well as in an interview with People magazine last month. Hilton claimed she was traumatized daily at the Provo Canyon School in Utah, where she was enrolled for 11 months at age 17.

Provo Canyon School previously responded to People magazine’s original report, telling Fox News in a statement at the time: “Originally opened in 1971, Provo Canyon School was sold by its previous ownership in August 2000. We therefore cannot comment on the operations or patient experience prior to this time.”

Provo Canyon School did not immediately respond to Fox News’ request seeking additional comment.

PARIS HILTON’S BOARDING SCHOOL ABUSE: FORMER CLASSMATES REVEAL NEW DETAILS, DUB STAR A ‘HERO’

Now, the hotel heiress and pop culture phenomenon is calling for the facility to be shut down in a new video shared on her YouTube Channel on Monday.

“I was abused at Provo Canyon School,” Hilton, dressed in a sharp white blazer, claimed in the video, which is titled: “SHUT DOWN PROVO CANYON SCHOOL.”

Paris Hilton previously alleged she was traumatized daily at the Provo Canyon School in Utah, where she was enrolled for 11 months at age 17. The boarding school has said that it was 'originally opened in 1971' and 'was sold by its previous ownership in August 2000. We therefore cannot comment on the operations or patient experience prior to this time.' (Photo by Tibrina Hobson/WireImage)

Paris Hilton previously alleged she was traumatized daily at the Provo Canyon School in Utah, where she was enrolled for 11 months at age 17. The boarding school has said that it was ‘originally opened in 1971’ and ‘was sold by its previous ownership in August 2000. We therefore cannot comment on the operations or patient experience prior to this time.’ (Photo by Tibrina Hobson/WireImage)

Below the video, Hilton alleges that “Provo took away my childhood among thousands of other survivors, as early as 9 years old.” She added that “while this movement is so personal to me, it is much bigger than just my experience.”

The 39-year-old further maintained in the clip that she plans to “put all my effort into reforming the industry.”

PARIS HILTON DETAILS ALLEGED ABUSE AT UTAH BOARDING SCHOOL FOR THE FIRST TIME: ‘CONTINUOUS TORTURE’

In addition, Hilton plugged a Change.org petition, which had over 40,000 signatures at the time of publishing. She has been pushing for reform on her Twitter account as well.

“This Is Paris,” a recent documentary centered on Hilton’s upbringing and wild teenage years which aired on YouTube earlier this month, put the Utah school on notice and shed light on the #BreakingCodeSilence initiative Hilton and her former Provo classmates launched to expose the industry.

Paris Hilton. (Photo by Willy Sanjuan/Invision/AP, File)

Paris Hilton. (Photo by Willy Sanjuan/Invision/AP, File)

A memorandum has since been placed on the boarding school’s website just below the masthead, referencing the Hilton’s documentary.

PARIS HILTON SAYS SHE WAS PHYSICALLY AND EMOTIONALLY ABUSED IN PAST RELATIONSHIPS

“We are aware of a new documentary referencing Provo Canyon School (PCS),” the note reads. “Please note that PCS was sold by its previous ownership in August 2000. We therefore cannot comment on

Emotional Abuse Silent Treatment Can Affect Your Physical, As Well As Emotional, Health.

A penis rash can appear as a reddened space of the skin or as small, pink bumps which may be accompanied by irritation, itching and soreness. Some individuals will swear that motorbike riding promotes healthy mind growth. The benchmarks still restrict visits and lifelong monetary benefits, which doesn’t occur for medical or surgical advantages (Nguyen). The rationale for the rating is that for adults with mental health, Florida ranked 25 out of fifty one; for children, 29 out of 51, which shows that children in Florida fare worse than adults in relation to receiving mental health companies (Nguyen).

The supply of unhealthy and low-cost meals makes it difficult for Hawaiians to make healthier decisions. Lastly, after learning to eat right, exercise, and create good habits in her life with constructive pondering and optimistic folks, she included line dancing in her routine for good health.

Physical train is considered important for sustaining bodily fitness and general health (including healthy weight), building and sustaining healthy bones, muscle tissue and joints, promoting physiological effectively-being, reducing surgical dangers, and strengthening the immune system.

Even literate, effectively-educated people typically have misguided views about what makes or retains them healthy, often believing that common daily train, regular bowel movements, or a specific dietary regime will alone suffice to protect their good health.

Moreover, OIG legal authorities permit hospitals and others to offer bonafide reductions to uninsured patients and to Medicare or Medicaid beneficiaries who cannot afford their health care bills. You are healing your mind as you are taking time to mentally rejuvenate from your busy day spent working, juggling household priorities and maintaining the home.…

Emotional Abuse Silent Remedy Can Affect Your Bodily, As Properly As Emotional, Health.

There may be some primary physiology that results how stress impacts ones health. The primary things this law required from insurance corporations was that they could not cost larger copays and deductibles for psychological health and substance abuse benefits than for medical and surgical advantages, mental health and substance abuse advantages had to be the identical scope or length as different advantages, extra authorizations could not be required for psychological health and substance abuse benefits, and the choice for psychological health and substance abuse providers and prescriptions had to be equal to that for medical and surgical (Ollove).

Perhaps now you may see why cayenne is thought to be a “miracle herb.” With over seven-hundred,000 People experiencing a stroke each year and virtually half one million dying of coronary heart illness, the remedy to a healthy coronary heart is as shut as your native grocery store.

Many who are suffering from delicate skin are realizing how several of the cruel skin care products on the market right this moment not only impact their pores and skin condition, however general well being as effectively. This paper explores a research on the use of yoga to improve the standard of life for female sufferers with breast cancer.

In an article by Snyder et al. (2011), countries who proceed to simply accept patients from other lands for costly providers run the danger of both pricing out poorer residents, or making a second tier of medical care in these nations. Somewhat than be an imposing and daunting problem to understand, the result will be growth of risk management methods to guide the delivery of health care.

• A heart that is healthy and powerful will allow the body to operate extra effectively. Given under is the description of some of the most common advantages of CBD oil for cancer sufferers. Your affected person could have a 3-day keep in the hospital and have 5 different nurses deal with them.…

Emotional Abuse Silent Treatment Can Affect Your Physical, As Effectively As Emotional, Health.

A penis rash can appear as a reddened space of the pores and skin or as small, pink bumps that may be accompanied by inflammation, itching and soreness. Blackberries are a significant supply of Vitamin E. You need this vitamin for healthy skin. The ten healthiest meals are foods which can be so exceptionally good for us that we should always include them in our healthy food regimen on a regular basis. Sufferers should have the ability to receive quality care, regardless if they’ve cash or not, and regardless if they dwell in a more developed country or not.

Healthy individuals are capable of mobilise all their physical, psychological, and non secular sources to improve their possibilities of survival, to reside completely happy and fulfilling lives, and to be of profit to their dependants and society. Turkey is one of the leanest protein foods and is low in energy, making it an excellent healthy meals alternative.

On condition that long term silent remedy emotional abuse creates anxiousness, and anxiousness in general, can result in continual stress and an assortment of medical issues, these on the receiving finish of the cold shoulder from their spouse need to take excellent care of themselves to assist preserve both their mental and bodily health.

The usage of slaves for medical experimentation was preventable as a result of vital advances in medical care have been made within the nineteenth century by Southern physicians who experimented in an moral method utilizing white ladies from whom they obtained knowledgeable consents.

Maybe now you can see why cayenne is regarded as a “miracle herb.” With over seven-hundred,000 People experiencing a stroke every year and nearly half a million dying of coronary heart disease, the treatment to a healthy coronary heart is as shut as your local grocery retailer.…

Emotional Abuse Silent Therapy Can Affect Your Physical, As Properly As Emotional, Health.

The term health and wellness are regularly used interchangeably, but the meanings are slightly completely different from each other. While you receive report at the beginning of your shift the very first thing it’s best to do is go set up contact together with your sufferers and decide which ones are having pain and want intervention at that very moment. Also, many hospitals present incentives to recruit a doctor or different health care professional to affix the hospital’s medical staff and provide medical companies to the encircling community.

While it’s optimum to offer every patient with the very best quality of care it is maybe higher to have the ability to afford to provide all patients with both high quality and affordable care. One supply, Snyder et al. (2011), informs that such treatment has been beneficial to patients who’re on ready lists for care, who have no health insurance coverage or are underinsured, or those that wish to entry experimental or unlawful therapies.

Blackberries are a serious source of Vitamin E. You need this vitamin for healthy skin. The 10 healthiest foods are meals which can be so exceptionally good for us that we should always include them in our healthy eating regimen regularly. Patients ought to have the ability to obtain quality care, regardless if they’ve cash or not, and regardless in the event that they dwell in a more developed country or not.

Although the United States has come a great distance in making mental health and substance abuse a known situation that needs to be addressed, it nonetheless has an extended method to go together with lessening the adverse stigma that encompasses mental health and substance abuse and likewise making certain that insurance coverage firms adjust to federal mandate of parity with psychological health and substance abuse advantages.

The various fatty meals folks favor to snack on nowadays include ldl cholesterol and unhealthy fats that find yourself clogging the arteries situated within the coronary heart region. By means of intensive research on Hawaiian tradition, meals, assimilation and historic occasions, this paper analyzes each the benefits of Hawaii’s ethnic amalgamation and the unfortunate effects of unhealthy, common foods in Hawaii.…